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Connecting Nerves
to Technology

Next-generation tissue-engineered neural interfaces that create bidirectional communication between the peripheral nervous system and digital technology.

Proudly partnered with

Axogen
About

Bridging biology
and electronics

Supported by patented IP developed at the University of Florida

Axolink is commercializing patented peripheral nerve interface technology from the University of Florida. Our platform integrates dense 3-D microelectrode arrays into decellularized nerve allografts to create a fundamentally new class of neural interface.

Unlike traditional approaches that use rigid electrodes, our technology promotes natural nerve regeneration around the electrodes — enabling intimate, long-term integration with minimal foreign body response.

By focusing on the peripheral nervous system, we deliver a safer, more accessible pathway to bidirectional neural connectivity across prosthetics, pain management, bioelectronic medicine, and beyond.

A-RPNI
Allograft Regenerative Peripheral-Nerve Interface
3D
Dense Volumetric Electrode Arrays
2-Way
Bidirectional Recording & Stimulation
ECM+
Native Extracellular Matrix Scaffold
Services

Clinical-grade microsurgical execution

Preclinical nerve repair, reconstruction, and device integration.

01

Precision Microsurgery

Clinical-grade microsurgical execution for preclinical nerve repair, reconstruction, and device integration.

02

Preclinical Peripheral Nerve Repair

Sciatic models. Nerve transection. Allografts. Conduits. Tension-free, reproducible reconstruction.

03

Reconstructive Techniques

TMR. RPNI. Hybrid nerve reconstruction. Executed with true surgical fidelity.

04

Neural Interface Implantation

Intra-nerve and intra-graft electrode placement. Seamless integration with regenerating tissue.

05

Chronic Survival Models

Weeks to months. Stable lead management. Reliable outcomes.

06

Custom Surgical Development

Device-specific implantation strategies. Iterative refinement. Translation-focused design.

07

Surgical Foundation

Reconstructive plastic surgery–based technique. Refined through annual hands-on cadaver training with AASH, ASPN, and ASRM in nerve repair, fixation, and flap reconstruction.

Technology

Built on the
A-RPNI platform

Stingray-shaped polyimide microelectrode arrays integrated into decellularized nerve allografts, leveraging native ECM architecture to guide axon regeneration directly around electrodes.

01

Stingray Thread Arrays

Stingray-shaped polyimide-metal microelectrode arrays enabling two parallel thread sets from a single bond-pad array — maximizing channel density while simplifying packaging and surgical complexity.

02

Decellularized Nerve Allografts

Clinically proven nerve allografts preserve native ECM architecture and structural cues, providing superior axonal guidance compared to synthetic hydrogel scaffolds.

03

Regenerative Integration

Nerves regenerate naturally through the allograft and around the 3-D microelectrode array, achieving intimate electrode-tissue contact with improved geometric stability.

Read the paper here.

Applications

Transforming human capability

01

Advanced Prosthetic Control

Thought-driven prosthetic limb control with naturalistic sensory feedback, restoring high-degree-of-freedom movement and the sense of touch for amputees.

02

Chronic Pain Neuromodulation

Targeted peripheral nerve stimulation that modulates pain signaling directly, offering precise, drug-free alternatives for chronic pain and phantom limb pain.

03

Bioelectronic Medicine

Precision stimulation of peripheral nerve pathways to modulate organ function, treating inflammatory, metabolic, and autoimmune conditions at their neural origin.

04

Human-Machine Integration

Seamless neural interfaces for next-generation devices, from surgical robotics to industrial exoskeletons, extending the boundaries of human performance.

Leadership

Founded by researchers,
built for patients

Deep expertise in neural engineering, biomedical device development, and MEMS microfabrication from the University of Florida.

Bassam M. Smadi, PhD
Bassam M. Smadi, PhD
Founder
Plastic surgery trained microsurgeon and biomedical engineer focused on peripheral nerve repair and neural interfaces. PhD, University of Florida Pruitt Department of Biomedical Engineering. Expertise in nerve reconstruction, neural electrode systems, and regenerative interface design.
David Hall, PhD
David Hall, PhD
Chief Technology Officer
PhD from University of Florida Pruitt Department of Biomedical Engineering with a specialty in remote neurostimulation, machine learning, and artificial intelligence applications.
Fares Smadi, CFA
Fares Smadi, CFA
Chief Investment Officer
Chief Investment Officer at Axolink. With a background in equity research and financial analysis, he combines fundamental insight and quantitative rigor to identify high-conviction opportunities across global markets.
Vision

The future of neural connectivity starts at the periphery

We believe tissue-engineered peripheral nerve interfaces will reshape how humans interact with technology.

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Contact

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